Crosstalk Involved in Liver Inflammation and Hepatocellular Carcinoma

1. Abstract
Hepatocellular carcinoma (HCC) usually occurs at the background of inflammation and cirrhosis. Due to the unique anatomic location
and the immunosuppressive environment of the liver, chronic inflammation causes intrahepatic cells death and elevated oxidative
stress levels, leading to the occurrence and development of HCC. In addition, the failure of immune system regulation and surveillance plays an important role in the development of HCC.