Involvement of Interleukin-6 induced PI3K/Akt/mTor pathway in the regulation of telomerase and Alpha-fetoprotein expression in Hepatocellular Carcinoma

1. Abstract 1.1. Background: Hepatocellular Carcinoma (HCC) is an invasive cancer. Alphafoetoprotein (AFP) is a diagnostic marker for HCC directly related to the disease agressivity. Telomerase, is expressed by 90% of HCC. PI3K/Akt/mTOR pathway wich is regulated by IL-6 is activated in the HCC. Our aim is to investigate the effect of IL-6 on AFP and telomerase secretion in HepG2/C3A and PLC/ PRF/5 cell lines.