Triple-Negative Breast Cancer: Is it Possible to Reverse Receptor Negativity and Regain Sensitivity to Receptor-Targeting Therapies?

Effective treatment of Triple-Negative Breast Cancer (TNBC) is lacking due to the absence of Estrogen Receptor (ER), Progesterone Receptor (PR) and human epidermal growth factor receptor 2 (HER2). The recent study showed that inactivation of ER is associated with hypermethylation of the ER promoter, MAPK signaling pathways, estrogen withdrawal, and hypoxia...