Effect of Pancreatic Juice and Bile Reflux to the Development of Esophageal Carcinogenesis in Rat Model

Reflux of duodenal contents contributes to the development of esophageal mucosal lesion. Esophageal cancer after total gastrectomy has been associated with the reflux of duodenal content ( biliary and pancreatic juice) into the esophagus. This study is to determine which fraction of the duodenum content, reflux, pancreatic juice or bile acids contributes to the development of esophageal cancer...