Transfection of Cis-element ‘Decoy’ AP-1 DNA Binding Sequences Inhibits expression of uPA, uPAR and VEGF in Salivary Gland Cancer Cells

The effects of inhibition of transcription factor AP-1 on synthesis of urokinase type plasminogen activator (uPA), uPA Receptor (uPAR), and Vascular Endothelial Growth Factor (VEGF) were determined using cultured salivary gland carcinoma cells (ACCS and ACCT cells). The expression of uPA, uPAR and VEGF was induced in the presence of EGF.