Advances in Diagnosis and Treatment for Nodal and Gastrointestinal Follicular Lymphomas Focused on Gene Targeted and Immune Therapeutic Agents

Advances in Diagnosis and Treatment for Nodal and Gastrointestinal Follicular Lymphomas Focused on Gene Targeted and Immune Therapeutic Agents

1. Abstract
Follicular lymphoma (FL), the most prevalent indolent B-cell lymphoma (BCL) globally, has seen rising incidence in Asia, Europe, and the USA, particularly in gastrointestinal cases. Genetic anomalies such as t(14;18), BCL2 overexpression, NFκB pathway factors, and histone modifiers contribute to FL development and proliferation.